The list is nearly all Spider-Mab and FF because the early issues of these comics are among the greatest comic books of all time.
- The Amazing Spider-Man #1: 1st Chameleon; meets Fantastic 4, introducing idea of “shared universe”
- Fantastic Four #12: 1st Thing vs Hulk Fight
- The Amazing Spider-Man #3: 1st Doctor Octopus
- Fantastic Four #13: 1st Watcher
- Fantastic Four #10: 1st Stan and Jack
- The Amazing Spider-Man #7: 1st Vulture
- Fantastic Four #11: 1st Impossible Man and Willie Lumpkin
- Strange Tales #115: Origin of Dr. Strange
- The Amazing Spider-Man #5: vs Doctor Doom
- Avengers #1: 1st “assembled” team