This is the first female supervillain Spider-Man fights.
So technically it’s the first time he hits a girl.
The fight is an accident. Her ridiculous flying craft accidentally cuts Spider-Man’s web while he’s swinging.
She beats him pretty easily, which doesn’t make a lot of sense.
Then she leaves. She recognizes that he’s not average, but somehow it still reads like an insult. The reason she needs an average man is because she’s been invited to be the face of a new hair company in an ad campaign and wants to know if it’s worth doing.
Seriously. That’s the plot.
Spoiler alert: She decides not to do it.