The Christmas issue in which Spider-Man kills Santa.
OK, so not really. But it is a lot of fun.
Puppet Master makes Flash Thompson (in a Spider-Man suit) and Medusa wreak havoc at a toy store. The FF and Spidey save the day, but not before fake Spider-Man trashes Christmas for the children, which enables J. Jonah Jameson to prove to the little kiddos that Spidey is, in fact, a menace to society.