For his Inferno bit, Spider-Man has to fight the New York Public Library lions, which are brought to life along with vacuum cleaners, mailboxes, and other city items.
The NY Public Library is the last place Peter Parker sees his Uncle Ben alive in the first Sam Raimi Spider-Man movie.
After that, it’s a Mysterio conflict.
There’s also hints that Dr. Connors is going to go lizard again, and some hints that Harry Osborn might be going Goblin.
And Hobgoblin is stalking him.