Time for a multi-issue arc.
Deadpool’s healing factor is not working the way it used to. The way it’s shown is funny–T-Ray at Hellhouse bets Deadpool he can’t regrow a finger. Guess which finger?
Of course.
Deadpool reconnects with Siryn (romance!) and goes to talk to Doctor Killebrew, the guy who put Deadpool through the Weapon X program.
Killebrew says Deadpool needs a super-blood transfusion. Who has super blood?
By the way, it’s important to note that Deadpool is frequently triggered by various things–like seeing Doctor Killebrew again–which adds a gritty darkness to his constantly horny/cartoonishly violent personality. There’s a complexity here that we don’t often get in Marvel comics.
Yes, I said Deadpool is psychologically complex.
The infusion works, and Deadpool is cured–so he decides it’s time to kill Killebrew, but Siryn stops him.
And at the end of the issue, they’re friends with a possibility of love in the future.